Table 2 Description and evaluation use case 2
Use case | 2. Laryngectomy plus postoperative radio(system)therapy versus primary radio(system)therapy for the treatment of locally advanced laryngeal and hypopharyngeal cancer—results from the University Clinical Cancer Registry Regensburg |
|---|---|
Description | |
 Remark/objective | Center-specific question, though clinic-wide; deeper entity-related data analysis including outcome-analyses |
 Study design | Part 1 retrospective Part 2 prospective (based on part 1) |
 Data period | Since 2010 (before cancer registry law, before foundation of centers) |
 Opportunities | Large number of cases for the investigated center available in database Research possibility of the system sufficient to get an overview |
 Risks/limitations | Important parameters not available in database (e.g. details about operations, radio-oncology, comorbidities, toxicity etc.) Diagnosis often not well-defined (distinct point if time, clinical etc.) Inconsistent data quality (dependent on date of foundation of center Insufficient oncological basis dataset |
Evaluation | |
 Selection of software | Possibility of adaptation of forms of particular importance |
 Database/data migration | No loss of relevant data through migration → additionally needed structured data not available in former database |
 Data analysis process | Variety of variables necessary → completion of proposal possible in total, simplification of certain aspects in the document necessary Data extraction more complex due to need to connect data over different forms Statistics (i.e. descriptive, correlations) with training materials practicable, multivariate analysis with support from ZKS |